Nuclear Factor B Protects Pancreatic -Cells From Tumor Necrosis Factor- -Mediated Apoptosis
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چکیده
منابع مشابه
Regulation of Fas (CD95)-induced apoptosis by nuclear factor- B and tumor necrosis factor- in macrophages
BIN LU,1 LIYING WANG,2 DJORDJE MEDAN,1 DAVID TOLEDO,1 CHUANSHU HUANG,3 FEI CHEN,2 XIANGLIN SHI,2 AND YON ROJANASAKUL1 1Department of Basic Pharmaceutical Sciences, Health Sciences Center, West Virginia University, Morgantown 26506; 2Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; and 3Nelson Institute of Environmental M...
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Objective. Little apoptosis has been observed in rheumatoid arthritis (RA) synovial tissues. Tumor necrosis factor (TNF ) is expressed in the joints of patients with RA, yet RA synovial fibroblasts are relatively resistant to apoptosis induced by TNF . Recently, we demonstrated that FLIP is highly expressed in the RA joint. These studies were performed to determine if TNF -induced NFB controls ...
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AIMS We investigated the protective effects of agmatine against tumor necrosis factor (TNF)-alpha-induced apoptosis in transformed rat retinal ganglion cells (RGC-5 cell line). MAIN METHODS The RGC-5 cells were exposed to 50 ng/mL TNF-alpha for 48 h with or without presence of 100 microM agmatine as indicated. Cell viability was determined by lactate dehydrogenase (LDH) assay. Double staining...
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BACKGROUND Ischemia-reperfusion injury (IRI) significantly contributes to graft dysfunction after liver transplantation. Natural killer (NK) cells are crucial innate effector cells in the liver and express tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a potent inducer of hepatocyte cell death. Here, we investigated if TRAIL expression on NK cells contributes to hepatic IRI. ...
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Aging is associated with glucose intolerance. Arginase-II (Arg-II), the type-II L-arginine-ureahydrolase, is highly expressed in pancreas. However, its role in regulation of pancreatic b-cell function is not known. Here we show that female (not male) mice deficient in Arg-II (Arg-II) are protected from age-associated glucose intolerance and reveal greater glucose induced-insulin release, larger...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2003
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.52.5.1169